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KMID : 1044520170800010027
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Tuberculosis and Respiratory Diseases
2017 Volume.80 No. 1 p.27 ~ p.34
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Duration of Pulmonary Tuberculosis Infectiousness under Adequate Therapy, as Assessed Using Induced Sputum Samples
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Ko You-Sang
Shin Jeong-Hwan
Lee Hyun-Kyung
Lee Young-Seok
Lee Suh-Young
Park So-Young
Mo Eun-Kyung
Kim Chang-Hwan
Kim Chang-Hwan
Park Yong-Bum
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Abstract
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Background: A sputum culture is the most reliable indicator of the infectiousness of pulmonary tuberculosis (PTB); however, a spontaneous sputum specimen may not be suitable. The aim of this study was to evaluate the infectious period in patients with non?drug-resistant (DR) PTB receiving adequate standard chemotherapy, using induced sputum (IS) specimens.
Methods: We evaluated the duration of infectiousness of PTB using a retrospective cohort design.
Results: Among the 35 patients with PTB, 22 were smear-positive. The rates of IS culture positivity from baseline to the sixth week of anti-tuberculosis medication in the smear-positive PTB group were 100%, 100%, 91%, 73%, 36%, and 18%, respectively. For smear-positive PTB cases, the median time of conversion to culture negativity was 35.0 days (range, 28.0?42.0 days). In the smear-negative PTB group (n=13), the weekly rates of positive IS culture were 100%, 77%, 39%, 8%, 0%, and 0%, respectively, and the median time to conversion to culture-negative was 21.0 days (range, 17.5?28.0 days).
Conclusion: The infectiousness of PTB, under adequate therapy, may persist longer than previously reported, even in patients with non-DR PTB.
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KEYWORD
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Tuberculosis, Pulmonary, Mycobacterium tuberculosis, Infectious Disease Incubation Period, Induced Sputum
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